FGF-21 (FGF21) Mouse/Rat ELISA Kit

For the quantitative determination of mouse/rat FGF-21 concentrations in serum, plasma and cell culture supernatant samples. The assay has not yet been tested on cell or tissu<

Cross-reactivity: 100% with human FGF-21, no cross reactivity with other mouse, rat, or human proteins including mouse Mup-1, LCN2, adiponectin, or ANGPL4.

Fibroblast growth factor 21(FGF-21) is a novel protein that has been implicated in the regulation of lipid and glucose metabolism under fasting and ketotic conditions.. In murine models, FGF-21 is predominantly expressed in liver, but it also expressed in adipose tissue and pancreatic ß-cells. FGF-21 stimulates glucose uptake in adipocytes. It also protects animals from diet-induced obesity when overexpressed in transgenic mice and lowers blood glucose and triglyceride levels when administered to diabetic rodents. When administered daily for 6 weeks to diabetic rhesus monkeys, FGF-21 caused a dramatic decline in fasting plasma glucose, fructosamine, triglycerides, insulin, and glucagon. Furthermore, elevated plasma FGF-21 concentrations in humans appear to be related to the presence of hepatic and peripheral insulin resistance. Thus research into FGF21 and its biology is potentially very wide-ranging and Symansis is proud to offer a high quality, sensitive ELISA for FGF21 research.