FGF-21 (FGF21) Human ELISA Kit
Availability: In Stock
Uniprot Nu : Q9NSA1
Species Reactivity : Human
Applications : ELISA
Alternative Names: Fibroblast growth factor 21, FGF21
For the quantitative determination of human FGF-21 concentrations in serum, plasma and cell culture supernate samples.
Fibroblast growth factor 21 (FGF-21) is a novel protein that has been implicated in the regulation of lipid and glucose metabolism under fasting and ketotic conditions[1,2]. In murine models, FGF-21 is predominantly expressed in liver, but it also expressed in adipose tissue and pancreatic ß-cells[3,4]. FGF-21 stimulates glucose uptake in adipocytes. It also protects animals from diet-induced obesity when overexpressed in transgenic mice and lowers blood glucose and triglyceride levels when administered to diabetic rodents. When administered daily for 6 weeks to diabetic rhesus monkeys, FGF-21 caused a dramatic decline in fasting plasma glucose, fructosamine, triglycerides, insulin, and glucagon. Furthermore, elevated plasma FGF-21 concentrations in humans appear to be related to the presence of hepatic and peripheral insulin resistance.
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