Anti-STAT5B total Antibody
Catalog Number: 3014-2B
Availability: In Stock
Size:
100 µg
Uniprot Nu : P51692
Species Reactivity : Human, Mouse
Host : Sheep
Format : Affinity purified
Applications : WB, IP
Alternative Names: Signal transducer and activator of transcription 5B
Availability: In Stock
Species Reactivity : Human, Mouse
Host : Sheep
Format : Affinity purified
Applications : WB, IP
Alternative Names: Signal transducer and activator of transcription 5B
Qty:
| A variety of cytokines and growth factors use the JAK–STAT (Signal transducers and activators of transcription) signalling pathway to transmit extracellular signals to the nucleus. STATs are transcriptional factors that are phosphorylated and activated by JAK kinases or by receptor tyrosine kinases, resulting in the formation of homo- or heterodimers that translocate to the cell nucleus. STATs serve important functions in regulating cell survival, proliferation, and differentiation. STAT5 is activated by a wide range of cytokines such as interleukins, GM-CSF, erythropoietin, growth hormone and prolactin. Constitutive STAT5 activation is observed in leukaemias and many solid tumours. Symansis 3014-2B sheep polyclonal antibody to STAT5B works excellently in IP and IB applications. It is expected to also react well in IHC applications however that application is currently untested. |
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