CRP/C-Reactive Protein Rapid Human ELISA Kit

C-reactive protein (CRP) is a circulating protein mainly secreted from the liver. This acute phase protein consists of five identical non-glycosylated subunits of 23 kDa, that give rise to a symmetrically arranged globular protein with molecular weight of approximately 120 kDa.(1) It has long been recognized that CRP is closely related to immunology, inflammation and host defense, as a result it has been used as an inflammatory marker. However, the development of high-sensitivity CRP (hsCRP) ELISA had addressed its role in other clinical issues. There is accumulating evidence suggesting the important role that CRP plays in mediating cardiovascular diseases (CVD) and type 2 diabetes.(2-4) Normally CRP is presenting only in a trace amount in circulation (<1 ug/ml)(5-6) but can increase over 1,000-fold under acute inflammatory state. Individual with blood CRP levels <1 ug/ml, 1-3 ug/ml and >3 ug/ml is considered to have low, moderate and high risk, respectively, of CVD and myocardial infraction.(7) Therefore, blood CRP level has become a promising measure of CVD risk.(8-9)

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