IL-2 R β - Fc Chimera

IL-2Rb is found on the surface of human T cells and is glycosylated. Symansis' IL-2 R beta - Fc Chimera^hcx contains 20-40% carbohydrate by weight.

The biological effects of IL-2 are mediated through the IL-2 receptor, which is predominantly expressed on activated T cells, B cells and monocytes. There are three subunits that may associate in different combinations to form the IL-2 receptor. These subunits include IL-2Ra, IL-2Rb, which is shared with IL-15 receptor, and IL-2Rg, which is also known as the common cytokine receptor gamma chain, (gc) as it is shared with receptors for IL-4, IL-7, IL-9, IL-15 and IL-21.

1. Gaffen SL (2001) Cytokine 14: 63-77. 2. Asao H, et al. (1990) Int Immunol. 2: 469-72