FGF R4 - Fc Chimera

Symansis' FGF R4 - Fc Chimera^hcx contains 15-30% carbohydrate by weight, has N-linked oligosaccharides, shown by a drop in observed MW on SDS-PAGE after treatment with PNGase F, and may have O-linked oligosaccharides.

Densitometry of protein isoforms visualised by 2-DE. Spot trains are normal in human proteins and highlight the presence of multiple isoforms which differ according to their level of post-translational modification. The triangle indicates the theoretical MW and pI of the protein.

Fibroblast growth factors (FGFs) belong to a large family (23 human members) of mitogenic factors that signal by binding to the FGF receptors (FGFRs) along with heparin and heparin-like glycosaminoglycans (HLGAGs). FGFs have major roles in hematopoiesis, development, wound repair, angiogenesis and tumor growth. There are multiple receptor splice variants that produce a number of isoforms of the four FGFRs.

1. Eswarakumar VP, et al. (2005) Cytokine Growth Factor Rev. 16: 139-49.
2. Ezzat S & Asa SL (2005) Horm Metab Res. 37: 355-60.