TG101348

An orally bioavailable, small-molecule, ATP-competitive inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity.

JAK-2 with IC50=6 nM; related kinases FLT3 and RET are also sensitive, with IC₅₀=25 nM and IC₅₀=17 nM

IUPAC Name: N-tert-butyl-3-[[5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]
pyrimidin-4-yl]amino]benzenesulfonamide

InChI: InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-
14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,
18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31)

InChIKey: JOOXLOJCABQBSG-UHFFFAOYSA-N

Canonical SMILES : CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)OCCN4CCCC4

CID 16722836 SID 123089189

CAS #:936091-26-8