AKT-I-1/AKT-1-1/AKT-I.1, AKT 1-1

Catalog Number: SYAKT-I-1
Availability: In Stock
Size: 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

* Size:



Akt-I-1 inhibits only Akt1 (IC50 4.6 microM). Biochem J. 2005 Jan 15;385(Pt 2):399-408.


The compound did not inhibit Akt3 nor mutants lacking the PH (pleckstrin homology) domain at concentrations up to 250 microM. The compound is a reversible inhibitor, and exhibits a linear mixed-type inhibition against ATP and peptide substrate. In addition to inhibiting kinase activity of individual Akt isoforms, both inhibitors (AKT-I-1 & AKT-I-1,2) blocked the phosphorylation and activation of the corresponding Akt isoforms by PDK1 (phosphoinositide-dependent kinase 1).

"hcx" and "human proteins, human source" are being used as trade marks by Symansis Pty Ltd   |   © 2014 Symansis Pty Ltd  |   Website by Joe Bunting