MIP-1 α/CCL3

Human macrophage inflammatory protein-1-alpha (MIP-1a) is a member of the C-C chemokine family. It plays a role in the activation of the inflammatory response including the recruitment of leukocytes to the sites of infection. MIP-1a and MIP-1b are also the major HIV-suppressive factors produced by CD8+ T-cells.

Densitometry of protein isoforms visualized by 2-DE. Spot trains are normal in human proteins and highlight the presence of multiple isoforms which differ according to their level of post-translational modification. The triangle indicates the theoretical MW and pI of the protein.

1. Lentzsch S, et al. (2003) Blood 101: 3568-73.