LIF/Leukemia Inhibitory Factor

Leukemia Inhibitory Factor (LIF) is a lymphoid factor which promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation in rodents. LIF has a number of other activities including cholinergic neuron differentiation, control of stem cell pluripotency, bone and fat metabolism, mitogenesis of certain factor dependent cell lines and promotion of megakaryocyte production in vivo. Human and murine mature LIF exhibit a 78% sequence identity at the amino acid control. Human LIF is equally active on both human and mouse cells. Murine LIF is approximately 1000 fold less active on human cells, than hLIF. For a review of LIF please see Saito et al. (2005) Hum Cell. 18(3):135-41. Human LIF expressed in human HEK cells, fully glycosylated: Catalogue Number 3014C (5 micrograms) 3014D (10 micrograms)