G-CSF

Catalog Number: 1001
Availability: In Stock
Size: 5 µg, 10 µg
Species Reactivity : Human
Host : Human, HEK Cell Expessed
Uniprot Nu : P09919
Alternative Names: Pluripoietin

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Glycosylation of G-CSF is important in increasing its stability, and therefore biological activity, by preventing its inactivation by serum due to proteases and alpha (2) macroglobulin.

Densitometry of protein isoforms visualised by 2-DE. Spot trains are normal in human proteins and highlight the presence of multiple isoforms which differ according to their level of post-translational modification. The triangle indicates the theoretical MW and pI of the protein.Granulocyte colony stimulating factor (G-CSF) G-CSF is the primary extracellular regulator of granulopoiesis. It increases the production of neutrophils by stimulating proliferation and survival of specific bone marrow precursor cells and their differentiation into granulocytes. G-CSF production is inducible by cytokines including TNF-alpha, IL-1, GMCSF, IL-17 and IL-4.

1. Roberts AW (2005) Growth Factors 23: 33-41.

 

 

 

 

 

 

 


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