PIGF-1/PlGF-131/PLGF

Catalog Number: 6007
Availability: In Stock
Size: 5 µg, 10 µg
Uniprot Nu : P49763
Species Reactivity : Human
Host : Human, HEK Cell Expessed

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PlGF (Placental growth Factor) was isolated initially as a cDNA from a human placenta cDNA library PlGF is expressed also in human umbilical vein endothelial cells colon and mammary carcinomas. Placenta growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family of growth factors. PlGF and VEGF share primary structural as well as limited amino acid sequence homology with the A and B chains of PDGF. The biologically active form of this protein is a disulfide-linked dimer. The N-glycosylated dimeric protein is secreted and stimulates the proliferation of endothelial cell lines and supports angiogenesis.

 

PlGF has been renamed PlGF-1 after the discovery of PlGF-2 which has a 21 amino acid insertion not present in PlGF. PlGF-1  and PlGF-2  compete in a dose-dependent way with the 165 amino acid form of VEGF for receptor binding on endothelial cells. The PlGF proteins bind with high affinity to Flt1, but not to Flk1/KDR. Neuropilin-1 probably functions as a receptor for PlGF-2.

Symansis’s version of PIGF/PLGFHCX presented here matches the following protein:
UniProtKB/Swiss-Prot: P49763.2/P49763-2;Also known as: PlGF-131 or Isoform PlGF-1.

 

 

 

 


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